Song, Geyang; Yang, Liu; Li, Jing-Sheng; Tang, Wei-Jun; Zhang, Wei; Cao, Rui; Wang, Chao; Xiao, Jianliang; Xue, Dong published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Chiral Arylated Amines via C-N Coupling of Chiral Amines with Aryl Bromides Promoted by Light》.Category: bromides-buliding-blocks The article contains the following contents:
A method based on mol. Ni catalysis driven by light, which enabled stereoretentive C-N coupling of optically active amines, amino alcs. and amino acid esters with aryl bromides, with no need for any external photosensitizer was reported. The method was effective for a wide variety of coupling partners, including those bearing functional groups sensitive to bases and nucleophiles, thus providing a viable alternative to accessing synthetically important chiral N-aryl amines, amino alcs. and amino acids esters. Its viability was demonstrated by 92 examples with up to 99% ee. In addition to this study using 1-Bromo-2-isopropylbenzene, there are many other studies that have used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Category: bromides-buliding-blocks) was used in this study.
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary