Shen, Xiao-Qin; Yan, Xiao-Wei; Zhang, Xing-Guo published the artcile< A palladium-catalyzed ring-expansion reaction of cyclobutanols with 2-haloanilines leading to benzazepines and quinolines>, Product Details of C7H4BrF3, the main research area is quinoline acyl preparation; benzazepine aryl preparation oxidative rearrangement; cyclobutanol haloaniline ring expansion palladium catalyst.
A general synthesis of 2-aryl benzazepines I (Ar = biphenyl-4-yl, 2-naphthyl, thiophen-2-yl, benzodioxol-5-yl, etc.; R = H, Ph, benzyloxymethyl; R1 = H, Me; R2 = H, Me, F, Cl, CF3, CO2Me; R1R2 = -CH=CH-CH=CH-; R3 = H, Me, MeO, Cl) has been developed through palladium-catalyzed ring-expansion reactions of cyclobutanols II with 2-haloanilines 2-X-4-R3-5-R2-6-R1C6HNH2. The further oxidative rearrangement reaction of benzazepines I provided an efficient synthesis of 2-acyl quinolines III. These transformations feature the efficient construction of six- and seven-membered N-containing heterocycles from easily obtained materials with excellent functional group tolerance.
Chemical Communications (Cambridge, United Kingdom) published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (halo-). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Product Details of C7H4BrF3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary