《Selective Mechanochemical Monoarylation of Unbiased Dibromoarenes by In-situ Crystallization》 was published in Journal of the American Chemical Society in 2020. These research results belong to Seo, Tamae; Kubota, Koji; Ito, Hajime. Safety of 2,5-Dibromothiophene The article mentions the following:
Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of liquid, unbiased dibromoarenes under mechanochem. conditions selectively afford the monoarylated products Ar-Ar1 [Ar = 2-BrC6H4, 2-Br-4,5-di-FC6H2, 4-Br-3-thienyl; Ar1 = Ph, 4-MeOC6H4, 2-naphthyl, etc.]. The lower reactivity of the crystalline monoarylated products relative to the liquid starting materials should be attributed predominantly to the low diffusion efficiency of the former in the re-action mixture, which results in a selective monoarylation. The present study sheds light on a novel approach using in-situ phase transitions in solids to design selective organic transfor-mations that are difficult to achieve via conventional solution-based synthesis. In the experiment, the researchers used many compounds, for example, 2,5-Dibromothiophene(cas: 3141-27-3Safety of 2,5-Dibromothiophene)
2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene may be used in the preparation of soluble α,ω-diformyl-a-oligothiophenes.Safety of 2,5-Dibromothiophene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary