Schneider, Leon N.; Tanzer Krauel, Eva-Maria; Deutsch, Carl; Urbahns, Klaus; Bischof, Tobias; Maibom, Kristina A. M.; Landmann, Johannes; Keppner, Fabian; Kerpen, Christoph; Hailmann, Michael; Zapf, Ludwig; Knuplez, Tanja; Bertermann, Ruediger; Ignat’ev, Nikolai V.; Finze, Maik published an article in Chemistry – A European Journal. The title of the article was 《Stable and Storable N(CF3)2 Transfer Reagents》.Application In Synthesis of 4-Bromo-1-(bromomethyl)-2-fluorobenzene The author mentioned the following in the article:
Fluorinated groups are essential for drug design, agrochems., and materials science. The bis(trifluoromethyl)amino group is an example of a stable group that has a high potential. While the number of mols. containing perfluoroalkyl, perfluoroalkoxy, and other fluorinated groups is steadily increasing, examples with the N(CF3)2 group are rare. One reason is that transfer reagents are scarce and metal-based storable reagents are unknown. Herein, a set of CuI and AgI bis(trifluoromethyl)amido complexes stabilized by N- and P-donor ligands with unprecedented stability are presented. The complexes are stable solids that can even be manipulated in air for a short time. They are bis(trifluoromethyl)amination reagents as shown by nucleophilic substitution and Sandmeyer reactions. In addition to a series of benzylbis(trifluoromethyl)amines, 2-bis(trifluoromethyl)amino acetate was obtained, which, upon hydrolysis, gives the fluorinated amino acid-N,N-bis(trifluoromethyl)glycine.4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5Application In Synthesis of 4-Bromo-1-(bromomethyl)-2-fluorobenzene) was used in this study.
4-Bromo-1-(bromomethyl)-2-fluorobenzene(cas: 76283-09-5) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 4-Bromo-1-(bromomethyl)-2-fluorobenzene Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary