Application In Synthesis of o-BromobenzaldehydeIn 2020 ,《Construction of Various Bridged Polycyclic Skeletons by Palladium-Catalyzed Dearomatization》 was published in Angewandte Chemie, International Edition. The article was written by Mu, Xingye; Yu, Hanxiao; Peng, Henian; Xiong, Wenrui; Wu, Ting; Tang, Wenjun. The article contains the following contents:
In the presence of [Pd(cinnamyl)Cl]2, an arylbenzoxaphospholane ligand, and K2CO3 in toluene, bromoaryl-substituted bicyclic phenols such as I underwent dearomative cyclization reactions to yield tetracyclic arenes such as II; a variety of ring systems with differing bridging patterns and carbocyclic and heterocyclic linkers were prepared using the method. The method was used to prepare partial ring systems for the alkaloids aspernomine and strychnochromine and to prepare dracaenone analogs. Bis(bromophenyl)- and bis(bromobenzyl)-substituted bicycles underwent enantioselective desymmetrization by dearomative cyclization using [Pd(cinnamyl)Cl]2 and nonracemic arylbenzoxaphospholane ligands to give bromoaryl- and bromobenzyl-substituted tetracycles in 33-99% ee (absolute configuration undetermined). After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Application In Synthesis of o-Bromobenzaldehyde)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application In Synthesis of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary