Ma, Yuanyuan; Gao, Qianwen; Zhou, Lan; Liu, Shanshan; Cheng, Hong-Gang; Zhou, Qianghui published the artcile< Diversity-Oriented Synthesis of Flavones and Isoflavones via Palladium/Norbornene Cooperative Catalysis>, COA of Formula: C8H6BrFO2, the main research area is arylated chromone chemoselective preparation; iodochromone aryl bromide olefin Heck palladium catalyst norbornene; potassium trifluoroborate iodochromone aryl bromide Suzuki palladium catalyst norbornene; alkylating reagent potassium trifluoroborate iodochromone alkylation palladium catalyst norbornene.
Diversity-oriented synthesis of arylated chromones I [R = H, 6-F, 7-Cl, etc.; R1 = CH=CHC6H5, Ph, 2-thienyl, etc.; R2 = Me, 2-NO2C6H4, 2-CO2MeC6H4, etc.] from 3-iodochromones via palladium/norbornene cooperative catalysis was reported. The success of this research reliesd on the use of a unique bridge-head ester modified norbornene derivative as the mediator. Salient features of this include readily available starting materials regarding 3-iodochromones, ortho-C-H arylating and alkylating reagents and ipso-terminating reagents, broad substrate scope, good chemoselectivity, good step-economy and scalability. A large number of structurally diversified flavones, isoflavones and 2,3-diarylated chromones could be quickly prepared in a predictable manner. As showcased by the efficient formal synthesis of umbralisib, this chem. could be treated as another valuable addition to the toolbox of medicinal chemists.
Chinese Journal of Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, COA of Formula: C8H6BrFO2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary