Lu, Cong; Jing, Dong; Shen, Yanling; Luo, Jiajing; Zheng, Ke published the artcile< Redox-neutral access to 3,3'-disubstituted oxindoles via radical coupling reactions>, Recommanded Product: 3-Bromobenzotrifluoride, the main research area is arylpropanyl indolinone preparation; disubstituted oxindole redox active ester radical coupling.
In this paper, the results of using EDA complexes of in situ formed enolates with redox-active esters for radical-coupling reactions under mild conditions (metal-, photocatalyst-, and base-free) to afford (arylpropan-2-yl)indolin-2-ones I [R1 = H, Me, Boc; R2 = Me, Ph, 4-FC6H4, etc.; R3 = R4 = H, Me; R5 = Ph, 4-MeC6H4, 2-naphthyl, etc.] was reported. The leaving group from the substrate in these experiments was reused as a base in the reaction. This strategy could successfully be applied to a wide variety of primary, secondary, and tertiary alkyl radical precursors and oxindoles in radical-coupling reactions. The success of sunlight-driven transformation and gram-level synthesis via flow chem. delivered promising results for further application in industrial settings. Mechanistic investigation, including control experiments, and UV-vis spectroscopy provided insight into the mechanism.
Organic Chemistry Frontiers published new progress about Coupling reaction, homolytic. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Recommanded Product: 3-Bromobenzotrifluoride.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary