《Stannylation and Stille Coupling of Base-Sensitive Tetrahydroxanthones to Heteromeric Biaryls》 was published in Advanced Synthesis & Catalysis in 2015. These research results belong to Lindner, Stephanie; Nieger, Martin; Braese, Stefan. Safety of 3-Bromo-2-nitrobenzoic acid The article mentions the following:
Herein, the synthesis of heteromeric tetrahydroxanthone biaryls is described, a widespread core structure of many natural products. The development of both stannylation and Stille coupling procedures of base-sensitive tetrahydroxanthones enabled their coupling with benzene derivatives as well as with xanthenes. These methods provide access to structures that are analogous to parnafungin as well as to dimeric compounds similar to secalonic acid or (5R,5’R,6R,6’R,10aR,10’aR)-rel-(-)-5,5′-bis(acetyloxy)-10a,10’a-bis[(acetyloxy)methyl]-5,5′,6,6′,7,7′,10a,10’a-octahydro-1,1′,8,8′-tetrahydroxy-6,6′-dimethyl-[2,4′-Bi-9H-xanthene]-9,9′-dione [i.e., phomoxanthone]. The synthesis of the target compounds was achieved using 7-bromo-2,3,4,4a-tetrahydro-1H-xanthen-1-one, 2,3,4,4a-tetrahydro-7-iodo-1H-xanthen-1-one (1R,4aS)-rel-7-bromo-2,3,4,4a-tetrahydro-1H-xanthen-1-ol as starting materials. Key intermediates for the coupling reactions included (tributylstannyl)xanthene derivatives Dimers thsu formed included 2,2′,3,3′,4,4′,4a,4’a-octahydro-[7,7′-bi-1H-Xanthene]-1,1′-dione. In the experimental materials used by the author, we found 3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4Safety of 3-Bromo-2-nitrobenzoic acid)
3-Bromo-2-nitrobenzoic acid(cas: 116529-61-4) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 3-Bromo-2-nitrobenzoic acid Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary