In 2016,Kaiser, Felix; Schmidt, Andrea; Heydenreuter, Wolfgang; Altmann, Philipp Johannes; Casini, Angela; Sieber, Stephan A.; Kuehn, Fritz Elmar published 《Self-assembled palladium and platinum coordination cages: Photophysical studies and anticancer activity》.European Journal of Inorganic Chemistry published the findings.Name: 3,5-Dibromoaniline The information in the text is summarized as follows:
Self-assembled coordination cages are interesting as drug delivery systems. Therefore, the synthesis of new ML (M = Pd, Pt) mol. cages, derived from highly fluorescent, rigid polyaromatic ligands is reported and the first PtL cage with a ligand consisting of three pyridine moieties is described. Photophys. properties were examined showing high quantum yields of up to 48% for the methoxy-functionalized ligands. Coordination of the ligands to palladium and platinum ions reduces the metallocages’ fluorescence, however. The host-guest chem. of the palladium cage with cisplatin is investigated confirming the encapsulation. The cages encapsulating cisplatin show a significantly increased cytotoxicity towards A549 (human lung adenocarcinoma) cells compared to cisplatin, and thus appear to be promising delivery vectors for the anticancer drug cisplatin. The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Name: 3,5-Dibromoaniline)
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: 3,5-Dibromoaniline
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary