《Biocidal polymers: synthesis, characterization and antimicrobial activity of bis-quaternary onium salts of poly(aspartate-co-succinimide)》 was written by El-Newehy, Mohamed H.; Meera, Moydeen A.; Aldalbahi, Ali K.; Thamer, Badr M.; Mahmoud, Yehia A.-G.; El-Hamshary, Hany. Quality Control of Methyltriphenylphosphonium bromideThis research focused onwater soluble biocidal polymer antimicrobial activity thermal stability; antimicrobial activity; poly(aspartate-co-succinimide); quaternary salts; water-soluble polymers. The article conveys some information:
Microbial multidrug resistance presents a real problem to human health. Therefore, water-soluble polymers based on poly(aspartate-co-succinimide) were synthesized via reaction of poly(aspartate-co-succinimide) with bis-quaternary ammonium or quaternary salts. The resultant copolymers were characterized by various techniques such as FTIR, TGA, 1HNMR, 13CNMR and elemental microanal. Antimicrobial activities of the new onium salts were investigated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonella typhi, and the fungi; Candida albicans, Aspergillus niger, Cryptococcus neoformans and Aspergillus flavus by agar diffusion method. Antimicrobial activity was studied in terms of inhibition zone diameters, in addition to the estimation of minimal inhibitory concentration (MIC) of the prepared compounds A. niger and E. coli were the most affected microorganisms among the tested microorganisms with an inhibition zone of 19-21 (mm) in case of biocides, (V) and (VII). The obtained results showed that the quaternary onium salts have higher activity compared to the aspartate copolymer with MIC concentrations of 25 mg/mL for (VII) and (V) and 50 mg/mL for (VI) and (IV). The results came from multiple reactions, including the reaction of Methyltriphenylphosphonium bromide(cas: 1779-49-3Quality Control of Methyltriphenylphosphonium bromide)
Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Quality Control of Methyltriphenylphosphonium bromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary