《Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Du, Hongtao; Jiang, Xinyu; Ma, Meng; Xu, Huili; Liu, Shuang; Ma, Fang. Quality Control of 4-Bromobutanoic acid The article mentions the following:
A novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids were synthesized and evaluated as acetylcholinesterase (AChE) and β-amyloid peptide (Aβ) aggregation inhibitors for the treatment of Alzheimer’s disease. The derivatives had multifunctional profiles, including AChE inhibition, Aβ1-42 aggregation inhibition, and neuroprotective properties. Inspiringly, hybrids (E)-4-((9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl 3-(1,3,4,9-tetrahydro-2H-pyrido [3,4-b]indol-2-yl)propanoate and (E)-4-((9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl 5-(1,3,4,9-tetrahydro-2H-pyrido [3,4-b]indol-2-yl)pentanoate displayed excellent inhibitory activities against hAChE (IC50 = 0.93 and 1.08 nM, resp.) and Aβ1-42 self-aggregation (IC50 = 19.71 and 2.05μM, resp.). In addition, (E)-4-((9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl 3-(1,3,4,9-tetrahydro-2H-pyrido [3,4-b]indol-2-yl)propanoate and (E)-4-((9-oxo-1,2-dihydropyrrolo[2,1-b]quinazolin-3(9H)-ylidene)methyl)phenyl 5-(1,3,4,9-tetrahydro-2H-pyrido [3,4-b]indol-2-yl)pentanoate showed low cytotoxicity and good neuroprotective activity against Aβ1-42-induced damage in SH-SY5Y cells.4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid) was used in this study.
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary