The author of 《Synthesis of binuclear isoquinoline- and pyridine-fused benzimidazole-4,7-diones by magnetic MOF-199-catalyzed C-C coupling/cyclization followed by oxidation》 were Diep, Thi Duyen; Dao, Pham Duy Quang; Cho, Chan Sik. And the article was published in European Journal of Organic Chemistry in 2019. HPLC of Formula: 6630-33-7 The author mentioned the following in the article:
Binuclear isoquinoline- and pyridine-fused benzimidazoles such as I [R = Ph, 4-FC6H4, 2-furyl, etc.; R1 = H, 3-Me, 2-F, 2-MeO] were prepared from 2-(2-bromoaryl)-4,7-dimethoxy-1H-benzo[d]imidazoles and (Z)-2-(2-bromovinyl)-4,7-dimethoxy-1H-benzo[d]imidazoles with 1,3-diketones by microwave irradiation in DMF in the presence of a catalytic amount of recyclable Fe3O4@SiO2@MOF-199 along with a base. Treatment of such binuclear N-fused hybrid scaffolds with ceric ammonium nitrate in acetonitrile/H2O or HBr/FeCl3 in H2O afforded binuclear isoquinoline- and pyridine-fused benzimidazole-4,7-diones II [R2 = Me, 2-MeC6H4, 4-MeOC6H4, etc.; R3 = H, 3-Me, 2-F, 2-MeO] in good to high yields. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7HPLC of Formula: 6630-33-7)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.HPLC of Formula: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary