Application of 6630-33-7In 2021 ,《Mildness in preparative conditions directly affects the otherwise straightforward syntheses outcome of Schiff-base isoniazid derivatives: Aroylhydrazones and their solvolysis-related dihydrazones》 was published in Journal of Molecular Structure. The article was written by Cukierman, Daphne S.; Evangelista, Beatriz N.; Neto, Carlos Castanho; Franco, Chris H. J.; Costa, Luiz Antonio S.; Diniz, Renata; Limberger, Jones; Rey, Nicolas A.. The article contains the following contents:
The two series of novel isoniazid-derived compounds prepared from a pair of different aldehyde precursors, as well as the solvolysis, under harsh synthetic conditions, of the initially formed aroylhydrazones, leaded to unexpected dihydrazones was described. All compounds were unequivocally characterized in solution using 1D and 2D NMR experiments in DMSO-d6 and, in the solid-state, by other classic techniques. System I was composed by 2-(1H-pyrazol-1-yl)benzaldehyde and its hydrazone derivatives, while system II comprised 2-(4-metoxyphenoxy)benzaldehyde and its related Schiff-base products. The first aldehyde was obtained for the first time via the copper-catalyzed Ullmann C-N coupling between 2-bromobenzaldehyde and pyrazole. Single crystals of its aroylhydrazone and dihydrazone derivatives were isolated and thoroughly characterized, included Hirshfeld surfaces and energy frameworks studies. Finally, it was described as NMR and theor.-based proposed reaction pathway for the unexpected formation of the dihydrazones involving the solvolysis of the initially formed isonicotinoyl hydrazone followed by attack to a second free aldehyde mol. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7It is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary