《Membrane-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics for Combating Multidrug-Resistant Bacteria》 was written by Chen, Huan; Li, Shengliang; Wu, Min; Kenry; Huang, Zhongming; Lee, Chun-Sing; Liu, Bin. Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:
Traditional photosensitizers (PSs) show reduced singlet oxygen (1O2) production and quenched fluorescence upon aggregation in aqueous media, which greatly affect their efficiency in photodynamic therapy (PDT). Meanwhile, non-targeting PSs generally yield low efficiency in antibacterial performance due to their short lifetimes and small effective working radii. Herein, a water-dispersible membrane anchor (TBD-anchor) PS with aggregation-induced emission is designed and synthesized to generate 1O2 on the bacterial membrane. TBD-anchor showed efficient antibacterial performance towards both Gram-neg. (Escherichia coli) and Gram-pos. bacteria (Staphylococcus aureus). Over 99.8% killing efficiency was obtained for methicillin-resistant S. aureus (MRSA) when they were exposed to 0.8μm of TBD-anchor at a low white light dose (25 mW cm-2) for 10 min. TBD-anchor thus shows great promise as an effective antimicrobial agent to combat the menace of multidrug-resistant bacteria. In the experiment, the researchers used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Recommanded Product: 1-Bromo-3,4,5-trimethoxybenzene)
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Referemce:
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