Cardinal-David, Benoit; Raup, Dustin E. A.; Scheidt, Karl A. published the artcile< Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenolates>, SDS of cas: 3893-18-3, the main research area is enal chalcone heterocyclic carbene Lewis acid catalyst stereoselective cyclization; cis trisubstituted cyclopentene stereoselective preparation.
A new approach that takes advantage of N-heterocyclic carbene/Lewis acid cooperative catalysis provides access to cis-1,3,4-trisubstituted cyclopentenes, e.g. I, from enals and chalcone derivatives with high levels of diastereoselectivity and enantioselectivity. The presence of Ti(OiPr)4 as the Lewis acid allows for efficient substrate preorganization, which translates into high levels of diastereoselectivity. Addnl., we demonstrate the possibility of controlling the absolute stereochem. of NHC-catalyzed reactions by employing a catalytic amount of a chiral Lewis acid as the unique source of optically active promoter.
Journal of the American Chemical Society published new progress about Alkenals Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, SDS of cas: 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary