Bricelj, Alesa; Dora Ng, Yuen Lam; Ferber, Dominic; Kuchta, Robert; Muller, Sina; Monschke, Marius; Wagner, Karl G.; Kronke, Jan; Sosic, Izidor; Gutschow, Michael; Steinebach, Christian published the artcile< Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands>, Application of C8H3BrO3, the main research area is PROTAC CRBN stability neosubstrate cereblon linker degradation.
Proteolysis targeting chimeras (PROTACs) hijacking the cereblon (CRBN) E3 ubiquitin ligase have emerged as a novel paradigm in drug development. Herein we found that linker attachment points of CRBN ligands highly affect their aqueous stability and neosubstrate degradation features. This work provides a blueprint for the assembly of future heterodimeric CRBN-based degraders with tailored properties.
ACS Medicinal Chemistry Letters published new progress about Cereblons Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Application of C8H3BrO3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary