Zhao, Guofeng; Wu, Yi; Wu, Hai-Hong; Yang, Junfeng; Zhang, Junliang published their research in Journal of the American Chemical Society in 2021. The article was titled 《Pd/GF-Phos-Catalyzed Asymmetric Three-component Coupling Reaction to Access Chiral Diarylmethyl Alkynes》.Computed Properties of C9H11Br The article contains the following contents:
Herein, a Pd-catalyzed enantioselective three-component coupling of N-tosylhydrazone, aryl halide and terminal alkyne under mild conditions utilizing a novel chiral sulfinamide phosphine ligand (GF-Phos), which provided a facile access to chiral diarylmethyl alkynes, the useful synthons in organic synthesis as well as exists as skeleton in many bioactive mols. was reported. A pair of enantiomers of the product could be easily prepared using the same chiral ligand by simply changing the aryl substituents of the N-tosylhydrazone, aryl halide. The salient features of this reaction included the readily available starting materials, general substrate scope, high enantioselectivity, ease of scale up, mild reaction conditions and versatile transformations. After reading the article, we found that the author used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Computed Properties of C9H11Br)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Computed Properties of C9H11Br In contrast, terrestrial plants account only for a few bromine-containing compounds.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary