In 2015,Zhang, Xi-Sha; Zhang, Yun-Fei; Li, Zhao-Wei; Luo, Fei-Xian; Shi, Zhang-Jie published 《Synthesis of Dibenzo[c,e]oxepin-5(7H)-ones from Benzyl Thioethers and Carboxylic Acids: Rhodium-Catalyzed Double C-H Activation Controlled by Different Directing Groups》.Angewandte Chemie, International Edition published the findings.COA of Formula: C8H7BrO2 The information in the text is summarized as follows:
A rhodium(III)-catalyzed cross-coupling of benzyl thioethers and aryl carboxylic acids through the two directing groups is reported. Useful structures with diverse substituents were efficiently synthesized in one step with the cleavage of four bonds, such as carbon-hydrogen bond (C-H bond), carbon-sulfur bond (C-S bond), oxygen-hydrogen bond (O-H bond) and the formation of two bonds (carbon-carbon bond C-C bond) and carbon-oxygen bond (C-O bond) formation. The formed structure is the privileged core in natural products and bioactive mols. This work highlights the power of using two different directing groups to enhance the selectivity of a double C-H activation, the first of such examples in cross-oxidative coupling. Under optimized conditions the synthesis of the target compounds was achieved using di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]dirhodium or tris(acetonitrile)[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl]rhodium(2+) bis[hexafluoroantimonate] as catalysts. Starting materials included benzyl thioethers, such as [(Methylthio)methyl]benzene derivatives and benzoic acid derivatives The title compounds thus formed included Dibenz[c,e]oxepin-5(7H)-one derivatives, 3,9-dimethyldibenz[c,e]oxepin-5(7H)-one. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2COA of Formula: C8H7BrO2)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. COA of Formula: C8H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary