Application In Synthesis of Methyltriphenylphosphonium bromideIn 2019 ,《Regio- and Enantioselective C-H Cyclization of Pyridines with Alkenes Enabled by a Nickel/N-Heterocyclic Carbene Catalysis》 appeared in Journal of the American Chemical Society. The author of the article were Zhang, Wu-Bin; Yang, Xin-Tuo; Ma, Jun-Bao; Su, Zhi-Ming; Shi, Shi-Liang. The article conveys some information:
Annulated pyridines are ubiquitous scaffolds in many bioactive mols. A highly regio- and enantioselective Ni(0)-catalyzed endo-selective C-H cyclization of pyridines with alkenes was developed. An unprecedented enantioselective C-H activation at pyridyl 3- or 4-positions was enabled by bulky chiral N-heterocyclic carbene ligands. This protocol provides expedient access to a series of optically active 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines, compounds otherwise accessed with difficulty, in moderate to high yields (up to 99% yield) and enantioselectivities (up to 99% ee). To the authors’ knowledge, this is the first example of enantioselective C-H cyclization of pyridines to chiral annulated products.Methyltriphenylphosphonium bromide(cas: 1779-49-3Application In Synthesis of Methyltriphenylphosphonium bromide) was used in this study.
Methyltriphenylphosphonium bromide(cas: 1779-49-3) is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.Application In Synthesis of Methyltriphenylphosphonium bromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary