《Decarboxylative Bromination of Sterically Hindered Carboxylic Acids with Hypervalent Iodine(III) Reagents》 was published in Organic Process Research & Development in 2020. These research results belong to Watanabe, Ayumi; Koyamada, Kenta; Miyamoto, Kazunori; Kanazawa, Junichiro; Uchiyama, Masanobu. Electric Literature of C4H7Br The article mentions the following:
Sterically hindered three-dimensional (3D) alkyl halides are promising precursors for various reactions; however, they are difficult to synthesize via conventional reactions. Reported is an efficient and practical method for decarboxylative bromination of sterically hindered 3D aliphatic carboxylic acids using com. available (diacetoxyiodo)benzene and potassium bromide, one of the most stable and cheapest bromine sources in nature. The method features a metal-free/Br2-free system, mild reaction conditions, one-pot operation under air at room temperature, wide functional group compatibility, and gram-scale synthetic capability. This highly efficient reaction cleanly converts a broad range of carboxylic acids, the most inexpensive and readily available sources of highly strained/naturally occurring/drug-related scaffolds, into the corresponding alkyl bromides in good to high yields. In the part of experimental materials, we found many familiar compounds, such as (Bromomethyl)cyclopropane(cas: 7051-34-5Electric Literature of C4H7Br)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Electric Literature of C4H7Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary