In 2019,Bioorganic & Medicinal Chemistry Letters included an article by Wang, Jian-Ta; Peng, Jin-Gang; Zhang, Ji-Quan; Wang, Zhong-Xiao; Zhang, Yi; Zhou, Xun-Rong; Miao, Jing; Tang, Lei. Related Products of 14660-52-7. The article was titled 《Novel berberine-based derivatives with potent hypoglycemic activity》. The information in the text is summarized as follows:
Four series of berberine derivatives were designed and synthesized. All the synthetic compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The results showed that most of the tested compounds exhibited potent hypoglycemic activity, and the most potent compound I exhibited its potency by 3.23-fold of berberine, 1.39-fold of metformin and 1.20-fold of rosiglitazone, resp. Western blot assay indicated these novel berberine-based derivatives executed their glucose-decreasing activity via the activation of AMPK pathway. In the experiment, the researchers used many compounds, for example, Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 14660-52-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary