Vang, Zoua Pa; Reyes, Albert; Sonstrom, Reilly E.; Holdren, Martin S.; Sloane, Samantha E.; Alansari, Isabella Y.; Neill, Justin L.; Pate, Brooks H.; Clark, Joseph R. published their research in Journal of the American Chemical Society in 2021. The article was titled 《Copper-Catalyzed Transfer Hydrodeuteration of Aryl Alkenes with Quantitative Isotopomer Purity Analysis by Molecular Rotational Resonance Spectroscopy》.Name: Ethyltriphenylphosphonium bromide The article contains the following contents:
A copper-catalyzed alkene transfer hydrodeuteration reaction that selectively incorporates one hydrogen and one deuterium atom across an aryl alkene was described. The transfer hydrodeuteration protocol was selective across a variety of internal and terminal alkenes and was also demonstrated on an alkene-containing complex natural product analog. Beyond using 1H, 2H, and 13C NMR anal. to measure reaction selectivity, six transfer hydrodeuteration products were analyzed by mol. rotational resonance (MRR) spectroscopy. The application of MRR spectroscopy to the anal. of isotopic impurities in deuteration chem. was further explored through a measurement methodol. that was compatible with high-throughput sample anal. In the first step, the MRR spectroscopy signatures of all isotopic variants accessible in the reaction chem. were analyzed using a broadband chirped-pulse Fourier transform microwave spectrometer. With the signatures in hand, measurement scripts were created to quant. analyze the sample composition using a com. cavity enhanced MRR spectrometer. The sample consumption was below 10 mg with anal. times on the order of 10 min using this instrument-both representing order-of-magnitude reduction compared to broadband MRR spectroscopy. To date, these measurements represent the most precise spectroscopic determination of selectivity in a transfer hydrodeuteration reaction and confirm that product regioselectivity ratios of >140:1 were achievable under this mild protocol. In the part of experimental materials, we found many familiar compounds, such as Ethyltriphenylphosphonium bromide(cas: 1530-32-1Name: Ethyltriphenylphosphonium bromide)
Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Name: Ethyltriphenylphosphonium bromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary