Name: (Bromomethyl)cyclopropaneIn 2019 ,《Discovery of 1,2,3-triazole-based fibroblast growth factor receptor modulators》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Sakai, Hiroki; Inoue, Hidekazu; Toba, Tetsuya; Murata, Kenji; Narii, Nobuhiro; Shimmyo, Yoshiari; Igawa, Yoshiyuki; Matsumoto, Takahiro; Takemoto, Naohiro. The article contains the following contents:
To avoid production of a phospholipidosis-inducing metabolite, we replaced the amide structure of SUN13837 (1) with a 1,2,3-triazole. The resulting 1,2,3-triazole analog of 1 (compound 2) displayed greater neuroprotective activity than 1. Structural modification of 2 yielded compound 10, which showed improved neuroprotective activity and negligible mechanism-based inactivation against CYP3A4. In addition, installation of a Me group at the 5-position of 1,2,3-triazole of 10 significantly boosted the neuroprotective activity. These 1,2,3-triazole derivatives displayed reduced phospholipidosis risk, sufficient systemic exposure, and high central nervous system penetration, and therefore may be potentially useful agents for the treatment of neurodegenerative diseases. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Name: (Bromomethyl)cyclopropane)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Name: (Bromomethyl)cyclopropane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary