《Asymmetric Total Synthesis of (+)-Waihoensene》 was published in Journal of the American Chemical Society in 2020. These research results belong to Qu, Yongzheng; Wang, Zheyuan; Zhang, Zhongchao; Zhang, Wendou; Huang, Jun; Yang, Zhen. Category: bromides-buliding-blocks The article mentions the following:
The asym. total synthesis of (+)-waihoensene (I), which has a cis-fused [6,5,5,5] tetracyclic core bearing an angular triquinane, a cis-fused six-membered ring, and four contiguous quaternary carbon atoms, was achieved through a sequence of chem. reactions in a stereochem. well-defined manner. The total synthesis features the following: (1) Cu-catalyzed asym. conjugated 1,4-addition; (2) diastereoselective Conia-ene type reaction; (3) diastereoselective intramol. Pauson-Khand reaction; (4) Ni-catalyzed diastereoselective conjugated 1,4-addition; and (5) radical-initiated intramol. hydrogen atom transfer (HAT). Control experiments and d. functional theory calculations support the proposed HAT process.Methyltriphenylphosphonium bromide(cas: 1779-49-3Category: bromides-buliding-blocks) was used in this study.
Methyltriphenylphosphonium bromide(cas: 1779-49-3) is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary