Electric Literature of C7H5BrOIn 2019 ,《A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines》 was published in Journal of the American Chemical Society. The article was written by Ni, Shengyang; Padial, Natalia M.; Kingston, Cian; Vantourout, Julien C.; Schmitt, Daniel C.; Edwards, Jacob T.; Kruszyk, Monika M.; Merchant, Rohan R.; Mykhailiuk, Pavel K.; Sanchez, Brittany B.; Yang, Shouliang; Perry, Matthew A.; Gallego, Gary M.; Mousseau, James J.; Collins, Michael R.; Cherney, Robert J.; Lebed, Pavlo S.; Chen, Jason S.; Qin, Tian; Baran, Phil S.. The article contains the following contents:
Historically accessed through two-electron, anionic chem., ketones, alcs., and amines are of foundational importance to the practice of organic synthesis. After placing this work in proper historical context, this Article reports the development, full scope, and a mechanistic picture for a strikingly different way of forging such functional groups. Thus, carboxylic acids, once converted to redox-active esters (RAEs), can be utilized as formally nucleophilic coupling partners with other carboxylic derivatives (to produce ketones), imines (to produce benzylic amines), or aldehydes (to produce alcs.). The reactions are uniformly mild, operationally simple, and, in the case of ketone synthesis, broad in scope (including several applications to the simplification of synthetic problems and to parallel synthesis). Finally, an extensive mechanistic study of the ketone synthesis is performed to trace the elementary steps of the catalytic cycle and provide the end-user with a clear and understandable rationale for the selectivity, role of additives, and underlying driving forces involved. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Electric Literature of C7H5BrO)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Electric Literature of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary