In 2022,Lamiable-Oulaidi, Farah; Harijan, Rajesh K.; Shaffer, Karl J.; Crump, Douglas R.; Sun, Yan; Du, Quan; Gulab, Shivali A.; Khan, Ashna A.; Luxenburger, Andreas; Woolhouse, Anthony D.; Sidoli, Simone; Tyler, Peter C.; Schramm, Vern L. published an article in Journal of Medicinal Chemistry. The title of the article was 《Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1》.Safety of Methyl 3-bromopropanoate The author mentioned the following in the article:
Hypermethylation of CpG regions by human DNA methyltransferase 1 (DNMT1) silences tumor-suppression genes, and inhibition of DNMT1 can reactivate silenced genes. The 5-azacytidines are approved inhibitors of DNMT1, but their mutagenic mechanism limits their utility. A synthon approach from the analogs of S-adenosylhomocysteine, methionine, and deoxycytidine recapitulated the chem. features of the DNMT1 transition state in the synthesis of 16 chem. stable transition-state mimics. Inhibitors causing both full and partial inhibition of purified DNMT1 were characterized. The inhibitors show modest selectivity for DNMT1 vs. DNMT3b. Active-site docking predicts inhibitor interactions with S-adenosyl-L-methionine and deoxycytidine regions of the catalytic site, validated by direct binding anal. Inhibitor action with purified DNMT1 is not reflected in cultured cells. A partial inhibitor activated cellular DNA methylation, and a full inhibitor had no effect on cellular DNA methylation. These compounds provide chem. access to a new family of noncovalent DNMT chem. scaffolds for use in DNA methyltransferases. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Safety of Methyl 3-bromopropanoate)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Safety of Methyl 3-bromopropanoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary