《Visible-Light-Driven C4-Selective Alkylation of Pyridinium Derivatives with Alkyl Bromides》 was published in Journal of the American Chemical Society in 2020. These research results belong to Jung, Sungwoo; Shin, Sanghoon; Park, Seongjin; Hong, Sungwoo. Quality Control of (Bromomethyl)cyclopropane The article mentions the following:
Reported herein is a general strategy for the photochem. cross-coupling between N-amidopyridinium salts and various alkyl bromides under photocatalyst-free conditions, granting facile access to various C4-alkylated pyridines. This approach exploits the intriguing photochem. activity of electron donor-acceptor (EDA) complexes between N-amidopyridinium salts and bromide, which provides a photoactive handle capable of generating silyl radicals and driving the alkylation process. The robustness of this protocol was further demonstrated by the late-stage functionalization of complex compounds, e.g., dehydroepiandrosterone and oxaprozin, under mild and metal-free conditions. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Quality Control of (Bromomethyl)cyclopropane)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Quality Control of (Bromomethyl)cyclopropane
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary