Electric Literature of C8H15BrO2In 2018 ,《Synthesis and biological characterization of novel rose bengal derivatives with improved amphiphilicity for sono-photodynamic therapy》 was published in European Journal of Medicinal Chemistry. The article was written by Chen, Hai-Jun; Zhou, Xiao-Bin; Wang, Ai-Lan; Zheng, Bi-Yuan; Yeh, Chih-Kuang; Huang, Jian-Dong. The article contains the following contents:
Sono-Photodynamic therapy (SPDT) utilizing ultrasound and light has been demonstrated that this novel approach can lower dosage resulting in reduction of the potential side effects caused by sensitizers. Recently, a new formulation of rose bengal (RB) as an intralesional injection has completed clin. trials phase II for PDT treatment of melanoma cancer. However, the inherent unfavorable pharmacol. properties of RB hindered its extensive clin. development. With the aim to identify new RB derivatives (RBDs) with enhanced photodynamic and sonodynamic anticancer efficiency, a series of amphiphilic RBDs have been designed, synthesized and biol. characterized. Among them, RBD4 significantly improved cellular uptake and enhanced intracellular ROS generation efficiency upon light and ultrasound irradiation, resulting in dramatically improved anticancer potency. Notably, RBD4 has a relative potency similar to sinoporphyrin sodium (DVDMS), indicating its further potential application for SPDT. The experimental part of the paper was very detailed, including the reaction process of 8-Bromooctanoic acid(cas: 17696-11-6Electric Literature of C8H15BrO2)
8-Bromooctanoic acid(cas: 17696-11-6) acid is used in the synthesis of 8-(N-Methyl-4,4′-bipyridinyl)- octanoic acid. 8-Mercaptooctanoic acid was prepared from 8-bromooctanoic acid. And 8-Bromooctanoic Acid is a useful compound for sonodynamic therapy.Electric Literature of C8H15BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary