Zhan, Bei-Bei; Wang, Lei; Luo, Jun; Lin, Xu-Feng; Shi, Bing-Feng published the artcile< Synthesis of Axially Chiral Biaryl-2-amines by PdII-Catalyzed Free-Amine-Directed Atroposelective C-H Olefination>, Recommanded Product: 2-Bromo-4-isopropylaniline, the main research area is arylamine palladium chiral spiro phosphoric acid atroposelective olefination catalyst; axially chiral biarylamine stereoselective preparation; C−H olefination; atroposelectivity; biaryl-2-amines; chiral spiro phosphoric acids; palladium.
A simple and ubiquitously present group, free amine, is used as a directing group to synthesize axially chiral biaryl compounds by PdII-catalyzed atroposelective C-H olefination. A broad range of axially chiral biaryl-2-amines can be obtained in good yields with high enantioselectivities (up to 97% ee). Chiral spiro phosphoric acid (SPA) proved to be an efficient ligand and the loading could be reduced to 1 mol % without erosion of enantiocontrol in gram-scale synthesis. The resulting axially chiral biaryl-2-amines also provide a platform for the synthesis of a set of chiral ligands.
Angewandte Chemie, International Edition published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Recommanded Product: 2-Bromo-4-isopropylaniline.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary