Shan, Chao; Xu, Jinping; Cao, Liming; Liang, Chaoming; Cheng, Ruihua; Yao, Xiantong; Sun, Maolin; Ye, Jinxing published the artcile< Rapid Synthesis of α-Chiral Piperidines via a Highly Diastereoselective Continuous Flow Protocol>, Related Products of 576-83-0, the main research area is chiral piperidine preparation diastereoselective; butylsulfinyl imine Grignard reagent debromocyclization continuous flow.
A practical continuous flow protocol has been developed using readily accessible N-(tert-butylsulfinyl)-bromoimine and Grignard reagents, providing various functionalized piperidines (34 examples) in superior results (typically >80% yield and with >90:10 dr) within minutes. The high-performance scale-up is smoothly carried out, and efficient synthesis of the drug precursor further showcases its utility. This flow process offers rapid and scalable access to enantioenriched α-substituted piperidines.
Organic Letters published new progress about Cyclization (debromo-). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Related Products of 576-83-0.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary