Meng, He; Bai, Shiming; Qiao, Yu; He, Ting; Li, Weiyi; Ming, Jialin published the artcile< Rhodium-Catalyzed Three-Component Reaction of Alkynes, Arylzinc Chlorides, and Iodomethanes Producing Trisubstituted/Tetrasubstituted Alkenes with/without 1,4-Migration>, Safety of 3-Bromobenzotrifluoride, the main research area is alkene diastereoselective preparation; alkyne arylzinc chloride iodomethane rhodium catalyst three component.
A three-component reaction of alkynes, arylzinc chlorides and iodomethanes was found to proceed in the presence of a rhodium catalyst to give high yields of trisubstituted/tetrasubstituted alkenes I [R = 2-MeC6H4, 2-Me-4-MeOC6H3, 2-furyl, etc.; R1 = H, Me; R2 = Me, n-Pr, (CH2)4I, etc.; R3 = Me, n-Pr, (CH2)3OMe, etc.; R2R3 = (CH2)10]. The usual arylzinc chlorides only gave trisubstituted alkenes, generated through a migratory carbozincation-cross-coupling sequence, where 1,4-Rh migration from an alkenyl carbon to an aryl carbon occurred. In contrast, 5-membered heteroarylzinc chlorides only gave the tetrasubstituted alkenes via a carborhodation-cross-coupling pathway without 1,4-migration.
Organic Letters published new progress about Alkenes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Safety of 3-Bromobenzotrifluoride.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary