Hu, Di; Pi, Chao; Hu, Wei; Han, Xiliang; Wu, Yangjie; Cui, Xiuling published the artcile< Ru(III)-catalyzed construction of variously substituted quinolines from 2-aminoaromatic aldehydes (ketones) and isoxazoles: Isoxazoles as cyclization reagent and cyano sources>, Electric Literature of 29124-57-0, the main research area is aminoarom carbonyl compound isoxazole ruthenium catalyst cyclization; cyanoquinoline preparation green chem.
A Ru(III)-catalyzed annulation reaction of 2-aminoarom. aldehydes (ketones) and isoxazoles to afford diverse 3-cyanoquinolines was developed. Notably, isoxazole acted as a cyclization reagent and nontoxic cyano source via N-O bond cleavage and fragmentation. Variously substituted (especially 6- or 7-substituted) quinolines could be easily afforded. This procedure featured wide functional group compatibility, efficiency and avoiding toxic cyano source. Meanwhile, this protocol could be successfully applied to scale-up synthesis. Further chem. transformations of 3-cyanoquinoline could give some valuable skeletons, demonstrating its potential in synthetic application.
Chinese Chemical Letters published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 29124-57-0 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO, Electric Literature of 29124-57-0.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary