Fier, Patrick S.; Maloney, Kevin M. published the artcile< Direct Conversion of Haloarenes to Phenols under Mild, Transition-Metal-Free Conditions>, Related Products of 81107-97-3, the main research area is phenol preparation nucleophilic aromatic substitution Lossen rearrangement haloarene; hydroxylation electron deficient haloarene heteroarene acetohydroxamic acid.
A high-yielding and practical method for the synthesis of phenols from electron-deficient haloarenes and heteroarenes has been developed. The products are formed from acetohydroxamic acid as the hydroxide source via a novel SNAr reaction/Lossen rearrangement sequence. Notably, these reactions employ inexpensive and air-stable reagents, require no special handling, occur under mildly basic conditions, and form products in high yields in the presence of electrophilic and protic functionality. The utility of this methodol. is demonstrated by the high-yielding hydroxylation of two base-sensitive complex substrates.
Organic Letters published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary