Bolchi, Cristiano; Pallavicini, Marco; Rusconi, Chiara; Diomede, Luisa; Ferri, Nicola; Corsini, Alberto; Fumagalli, Laura; Pedretti, Alessandro; Vistoli, Giulio; Valoti, Ermanno published the artcile< Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency>, Safety of 2-Bromo-4-nitrobenzoic acid, the main research area is peptidomimetic inhibitor farnesyltransferase antiproliferative aorta smooth muscle atherosclerosis.
2-O-Tolyl or 2-o-anisyl substituted 4-hydroxy- and 4-carboxybenzamides of methionine, etherified and amidified with 2-hydroxymethyl- and 2-aminomethylpyridodioxane, resp., are described as inhibitors of Ras protein farnesyltransferase (FTase). Of the sixteen compounds, resulting from the substitution pattern of benzamide and the configuration of the two stereocenters, seven inhibited FTase activity with potencies in the nanomolar range. They were all 2-oxymethylpyridodioxane ethers and, among them, the four o-tolyl substituted stereoisomers also showed micromolar antiproliferative effect on human aortic smooth muscle cells interfering with Ras farnesylation. The docking anal. enlightened significant differences in enzyme interaction between oxymethylpyridodioxane and aminomethylpyridodioxane derivatives
Bioorganic & Medicinal Chemistry Letters published new progress about Antiatherosclerotics. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Safety of 2-Bromo-4-nitrobenzoic acid.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary