《Iridium(I)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids》 was written by Zeng, Linwei; Chen, Renjie; Zhang, Chen; Xie, Hujun; Cui, Sunliang. Synthetic Route of C4H7BrO2 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:
An iridium(I)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids was described. Various 2-alkynylphenols and carboxylic acids could be used in this process to furnish aromatic ortho-acyloxyketones I [R1 = H, 4-Me, 2-C≡CPh-4-Cl; R2 = n-Bu, Ph, 2-thienyl, etc.; R3 = Me, 2-naphthyl, Bn, etc.] via a regio- and stereo-selective addition reaction followed by intramol. rearrangement. Unexpectedly, changing the purification method of the products from silica gel column chromatog. to direct concentration or recrystallization resulted in exclusively obtaining (E)-enol esters II [R4 = Ph, 4-MeC6H4, 2-ClC6H4, 4-FC6H4; R5 = Ph, 2-MeC6H4, 2,4-di-O2NC6H3, etc.]. This protocol featured mild reaction conditions and broad substrate scope. To demonstrate the synthetic utility of this reaction, four obtained ortho-acyloxyketones were treated with NaH and subsequently refluxed in acetic acid gave flavones III [R1 = 2-furyl, 2-thienyl, 2-naphthyl, tetrahydropyran-4-yl]. The experimental process involved the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Synthetic Route of C4H7BrO2)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Synthetic Route of C4H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary