Xie, Yun-Dong; Xu, Yan-Hong; Liu, Ji-Ping; Wang, Bin; Shi, Yong-Heng; Wang, Wei; Wang, Xiao-Ping; Sun, Meng; Xu, Xin-Ya; Bian, Xiao-Li published their research in Bioorganic & Medicinal Chemistry Letters in 2021. The article was titled 《1,3-Benzodioxole-based fibrate derivatives as potential hypolipidemic and hepatoprotective agents》.Recommanded Product: Ethyl 5-bromovalerate The article contains the following contents:
A series of target compounds 1,3-benzodioxole-based fibrate derivatives were designed and synthesized. All the target compounds were preliminarily evaluated by hyperlipidemia mice induced by Triton WR-1339, in which compound I displayed a greater anti-hyperlipidemia activity than other compounds as well as pos. drug fenofibrate (FF). I showed a significant reduction of plasma lipids, such as triglycerides (TG), total cholesterol (TC) and low-d. lipoprotein cholesterin (LDL-C), in high fat diet (HFD) induced hyperlipidemic mice. In addition, hepatic transaminases (AST and ALT) were ameliorated after administration of I, in particular the AST, and the histopathol. examination showed that I improved the hepatic lipid accumulation. The expression of PPAR-α involved in lipids metabolism was up-regulated in the liver tissues of 12-treated group. Other significant activity such as antioxidant, and anti-inflammation was confirmed and reinforced the effects of I as a potential hypolipidemia and hepatoprotective agent.Ethyl 5-bromovalerate(cas: 14660-52-7Recommanded Product: Ethyl 5-bromovalerate) was used in this study.
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Ethyl 5-bromovalerate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary