《Design, Synthesis, and Herbicidal Activity of Thioether Containing 1,2,4-Triazole Schiff Bases as Transketolase Inhibitors》 was written by Wang, Yan-En; Yang, Dongchen; Huo, Jingqian; Chen, Lai; Kang, Zhanhai; Mao, Jianyou; Zhang, Jinlin. Application of 7051-34-5This research focused ontriazole Schiff base preparation herbicidal activity transketolase inhibitor; 1,2,4-triazole Schiff bases; herbicidal activity; molecular docking; transketolase; weed resistance. The article conveys some information:
Transketolase (TK) represents a potential target for novel herbicide development. To discover novel TK inhibitors with potency against resistant weeds, 36 thioether compounds containing 1,2,4-triazole Schiff bases were designed and synthesized for herbicidal activity evaluation. The results demonstrated that compounds I and II provided excellent weed control with inhibition of over 90% against the tested weeds, even at concentrations as low as 100 mg/L in vitro. In addition, compounds I and II exhibited higher postemergence herbicidal activity than all of the pos. controls against the tested weeds at 50-90 g [active ingredient (ai)]/ha in a greenhouse, while being safe for crops of maize and wheat at 90 g (ai)/ha. Fluorescent binding experiments of At TK indicated that compounds I and II had strong TK inhibitory activity and could tightly bind with the enzyme At TK. Also, mol. docking analyses revealed that the structures of compounds I and II were suitable for TK inhibitory activity. Taken together, these results suggested that compounds I and II were promising herbicide candidates for weed control in wheat and maize fields targeting TK. In the part of experimental materials, we found many familiar compounds, such as (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary