Usutani, Hirotsugu; Cork, David G. published an article in Organic Process Research & Development. The title of the article was 《Effective Utilization of Flow Chemistry: Use of Unstable Intermediates, Inhibition of Side Reactions, and Scale-Up for Boronic Acid Synthesis》.Formula: C12H15BrO The author mentioned the following in the article:
Flow chem. processes for boronic acid syntheses utilizing lithiation-borylation have been developed. The side reactions in the lithiation step that occur in batch were suppressed, and unstable lithium intermediates were handled safely. Flow technol. was applied to several kinds of boronic acid syntheses, and scale-up was successfully conducted to allow kilogram-scale production Some of the key benefits of flow flash chem. were utilized, both to avoid side reactions and to enable dianion chem. that is difficult to perform successfully in batch reactions. The examples showed further perspectives on the utility of flow technologies for process development. In the experimental materials used by the author, we found 1-Bromo-4-(cyclohexyloxy)benzene(cas: 30752-31-9Formula: C12H15BrO)
1-Bromo-4-(cyclohexyloxy)benzene(cas: 30752-31-9) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C12H15BrO In contrast, terrestrial plants account only for a few bromine-containing compounds.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary