Tlahuext-Aca, Adrian; Lee, Sarah Yunmi; Sakamoto, Shu; Hartwig, John F. published the artcile< Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis>, Quality Control of 401-78-5, the main research area is arene aryl bromide synergistic palladium silver catalyst regioselective arylation; biaryl preparation; C–H activation; aryl bromides; direct arylation; palladium and silver catalysts; synergistic catalysis.
The direct, catalytic arylation of simple arenes in small excess with aryl bromides was disclosed. The developed method did not require the assistance of directing groups and relies on a synergistic catalytic cycle in which phosphine-ligated silver complexes cleave the aryl C-H bond, while palladium catalysts enable the formation of the biaryl products. Mechanistic experiments, including kinetic isotope effects, competition experiments, and hydrogen-deuterium exchange, support a catalytic cycle in which cleavage of the C-H bond by silver is the rate-determining step.
ACS Catalysis published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Quality Control of 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary