Application of 7051-34-5In 2021 ,《Iron-Catalyzed Tertiary Alkylation of Terminal Alkynes with 1,3-Diesters via a Functionalized Alkyl Radical》 was published in Angewandte Chemie, International Edition. The article was written by Tian, Ming-Qing; Shen, Zhen-Yao; Zhao, Xuefei; Walsh, Patrick J.; Hu, Xu-Hong. The article contains the following contents:
Direct oxidative C(sp)-H/C(sp3)-H cross-coupling offers an ideal and environmentally benign protocol for C(sp)-C(sp3) bond formations. As such, reactivity and site-selectivity with respect to C(sp3)-H bond cleavage have remained a persistent challenge. Herein is reported a simple method for iron-catalyzed/silver-mediated tertiary alkylation of terminal alkynes with readily available and versatile 1,3-dicarbonyl compounds The reaction is suitable for an array of substrates and proceeds in a highly selective manner even employing alkanes containing other tertiary, benzylic, and C(sp3)-H bonds alpha to heteroatoms. Elaboration of the products enables the synthesis of a series of versatile building blocks. Control experiments implicate the in situ generation of a tertiary carbon-centered radical species. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary