Tian, Lei; Li, Jian; He, Mei published an article in 2021. The article was titled 《Synthesis of deuterium labeled ezetimibe and its glucuronide conjugate》, and you may find the article in Journal of Radioanalytical and Nuclear Chemistry.Computed Properties of C13H17BrO9 The information in the text is summarized as follows:
Ezetimibe is an effective cholesterol absorption inhibitor approved for the combined treatment with statins to reduce LDL-C level. Ezetimibe labeled with deuterium was applied for drug metabolism studies. [2H5] fluorobenzene was applied to preprare [2H4] ezetimibe. Stable isotope labeled ezetimibe was obtained in seven steps with a 29.3% overall yield. Stable isotope labeled glucuronide-ezetimibe, the most abundant metabolite of ezetimibe was also synthesized. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Computed Properties of C13H17BrO9)
(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Computed Properties of C13H17BrO9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary