Quality Control of Ethyl 4-bromobutyrateIn 2019 ,《Regioselective Alkylative Cross-Coupling of Remote Unactivated C(sp3)-H Bonds》 appeared in Journal of the American Chemical Society. The author of the article were Thullen, Scott M.; Treacy, Sean M.; Rovis, Tomislav. The article conveys some information:
The functionalization of unactivated C(sp3)-H bonds poses a significant challenge due to their ubiquity and relative similarity in most organic frameworks. Herein, we describe the use of a combined photoredox and nickel catalytic system for the regioselective C(sp3)-C(sp3) coupling of unactivated C(sp3)-H bonds and alkyl bromides. Positional selectivity is dictated by a 1,5-hydrogen atom transfer (HAT) reaction by a pendent amide. Interception of this radical by a Ni catalyst allows distal alkylation to occur in good yield and excellent selectivity. In the experimental materials used by the author, we found Ethyl 4-bromobutyrate(cas: 2969-81-5Quality Control of Ethyl 4-bromobutyrate)
Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Ethyl 4-bromobutyrate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary