Quality Control of Methyl 3-bromopropanoateIn 2018 ,《A Sulfoxide-Based Isobaric Labeling Reagent for Accurate Quantitative Mass Spectrometry》 was published in Angewandte Chemie, International Edition. The article was written by Stadlmeier, Michael; Bogena, Jana; Wallner, Miriam; Wuehr, Martin; Carell, Thomas. The article contains the following contents:
Modern proteomics requires reagents for exact quantification of peptides in complex mixtures Peptide labeling is most typically achieved with isobaric tags that consist of a balancer and a reporter part that sep. in the gas phase. An ingenious distribution of stable isotopes provides multiple reagents with identical mol. weight but a different mass of the reporter groups, allowing relative quantification of multiple samples in one measurement. Here the authors report a new isobaric labeling reagent, where the balancer and the reporter are linked by a sulfoxide group, which, based on the sulfoxide pyrolysis, leads to easy and asym. cleavage at low fragmentation energy. The fragmentation of the new design is significantly improved, yielding more intense complementary ion signals, allowing complementary ion cluster anal. as well. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Quality Control of Methyl 3-bromopropanoate)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Methyl 3-bromopropanoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary