《Synthesis and evaluation of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-one derivatives as vasorelaxing agents》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Singh, Sarita; Agarwal, Karishma; Iqbal, Hina; Yadav, Pankaj; Yadav, Deepika; Chanda, Debabrata; Tandon, Sudeep; Khan, Feroz; Gupta, Anil Kumar; Gupta, Atul. COA of Formula: C7H13BrO2 The article mentions the following:
A series of substituted 8,8-dimethyl-8H-pyrano[2,3-f]chromen-2-ones I [R = Me, (CH2)2NMe2, CH2C(O)N(Me)(n-Bu), etc.] was synthesized from scopoletin as vasorelaxing agents. The synthesized compounds were evaluated for vasorelaxation in endothelium intact rat main mesenteric artery (MMA). Scopoletin, and compounds I [R = Me, CH2C(O)N(Me)(n-Bu), (CH2)4C(O)N(Me)(n-Bu), CH2C(O)NH(n-pentyl), (CH2)3C(O)N(Me)(n-pentyl), (CH2)4C(O)NH(n-pentyl)] showed significant vasorelaxation in precontracted MMA within the range of EC50 value 1.58-5.02μM. These derivatives presented 29.40-70.89 fold increased sensitivity for exptl. tissue compared to scopoletin, the parent mol. Among others, compound I [R = Me] was found to be the most active compound which had EC50 1.58μM with 70.89 fold increased sensitivity. The mechanistic evaluation of compound I [R = Me] showed that it exerted vasorelaxation through Ca2+-activated K+ (BKca) channel and the effect was endothelium-independent. In the experimental materials used by the author, we found Ethyl 5-bromovalerate(cas: 14660-52-7COA of Formula: C7H13BrO2)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.COA of Formula: C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary