Sasmal, Arpan; Bera, Jitendra K.; Doucet, Henri; Soule, Jean-Francois published the artcile< Reactivity of antipyrine and haloantipyrines in Pd-catalyzed C-H bond arylations>, Related Products of 401-78-5, the main research area is aryl dimethyl phenyl pyrazolone green preparation; antipyrine aryl bromide arylation palladium catalyst.
Synthesis of 4-(aryl)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one I [Ar = 2-(1-methylpyrrolyl), 4-ClC6H4, 1-naphthyl, etc.;] via Pd-catalyzed direct arylation of antipyrine using Pd(OAc)2 as catalyst associated with KOAc as inexpensive base was reported. In most cases, di-Et carbonate was used a sustainable solvent. The reaction tolerated a wide range of functional groups on the aryl bromide partners (e.g., nitrile, nitro, chloro, fluoro, formyl, acetyl, propionyl, benzoyl, ester, Me, methoxy). In addition, some nitrogen-containing heteroaryl bromides were also efficiently coupled with antipyrine. We also demonstrated that in contrast to 4-bromoantipyrine, 4-iodoantipyrine could be employed as an efficient heteroaryl source in Pd-catalyzed C-H bond arylation of 5-membered ring heteroarenes.
Tetrahedron Letters published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Related Products of 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary