Reference of Methyl 3-bromopropanoateIn 2018 ,《Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Saleeb, Michael; Sundin, Charlotta; Aglar, Oeznur; Pinto, Ana Filipa; Ebrahimi, Mahsa; Forsberg, Aake; Schuler, Herwig; Elofsson, Mikael. The article conveys some information:
During infection, the Gram-neg. opportunistic pathogen Pseudomonas aeruginosa employs its type III secretion system to translocate the toxin exoenzyme S (ExoS) into the eukaryotic host cell cytoplasm. ExoS is an essential in vivo virulence factor that enables P. aeruginosa to avoid phagocytosis and eventually kill the host cell. ExoS elicits its pathogenicity mainly via ADP-ribosyltransferase (ADPRT) activity. The authors recently identified a new class of ExoS ADPRT inhibitors with in vitro IC50 of around 20 μM in an enzymic assay using a recombinant ExoS ADPRT domain. Herein, the authors report structure-activity relationships of this compound class by comparing a total of 51 compounds based on a thieno [2,3-d]pyrimidin-4(3H)-one and 4-oxo-3,4-dihydroquinazoline scaffolds. Improved inhibitors with in vitro IC50 values of 6 μM were identified. Importantly, the authors demonstrated that the most potent inhibitors block ADPRT activity of native full-length ExoS secreted by viable P. aeruginosa with an IC50 value of 1.3 μM in an enzymic assay. This compound class holds promise as starting point for development of novel antibacterial agents. The experimental process involved the reaction of Methyl 3-bromopropanoate(cas: 3395-91-3Reference of Methyl 3-bromopropanoate)
Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of Methyl 3-bromopropanoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary