Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acidOn October 15, 2022 ,《Development and profiling of mGlu7 NAMs with a range of saturable inhibition of agonist responses in vitro》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Reed, Carson W.; Rodriguez, Alice L.; Kalbfleisch, Jacob J.; Seto, Mabel; Jenkins, Matthew T.; Blobaum, Anna L.; Chang, Sichen; Lindsley, Craig W.; Niswender, Colleen M.. The article contains the following contents:
We describe here a series of metabotropic glutamate receptor 7 (mGlu7) neg. allosteric modulators (NAMs) with a saturable range of activity in inhibiting responses to an orthosteric agonist in two distinct in vitro pharmacol. assays. The range of inhibition among compounds in this scaffold provides highly structurally related ligands with differential degrees of receptor blockade that can be used to understand inhibitory efficacy profiles in native tissue or in vivo.2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acid) was used in this study.
2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 2-Bromo-5-(trifluoromethoxy)benzoic acid Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary