SDS of cas: 403646-48-0On May 15, 2019 ,《Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Reed, Carson W.; Washecheck, Jordan P.; Quitlag, Marc C.; Jenkins, Matthew T.; Rodriguez, Alice L.; Engers, Darren W.; Blobaum, Anna L.; Jeffrey Conn, P.; Niswender, Colleen M.; Lindsley, Craig W.. The article conveys some information:
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile amide moiety within a series of mGlu7 neg. allosteric modulators (NAMs). SAR rapidly honed in on either a 1,2,4- or 1,3,4-oxadizaole ring system as an effective bioisostere for the amide. Further optimization of the southern region of the mGlu7 NAM chemotype led to the discovery of VU6019278, a potent mGlu7 NAM (IC50 = 501 nM, 6.3% L-AP4 Min) with favorable plasma protein binding (rat fu = 0.10), low predicted hepatic clearance (rat CLhep = 27.7 mL/min/kg) and high CNS penetration (rat Kp = 4.9, Kp,uu = 0.65). In the part of experimental materials, we found many familiar compounds, such as 2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0SDS of cas: 403646-48-0)
2-Bromo-5-(trifluoromethoxy)benzoic acid(cas: 403646-48-0) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. SDS of cas: 403646-48-0 In contrast, terrestrial plants account only for a few bromine-containing compounds.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary