The author of 《Hydrazone linkage based Schiff base: synthesis, characterization and their biological applications》 were Pradhan, Alka Prof.; Koshal, Anil Kumar; Khichi, Dharmendra Singh. And the article was published in World Journal of Pharmaceutical Research in 2019. Product Details of 6630-33-7 The author mentioned the following in the article:
Synthesis of hydrazone linkage based Schiff base derivatives I [X = H, OH, Cl, Br; Y = H, 4-NO2, 4-NH2] via condensation of 2-[1-(4-aminophenyl)ethylidene]-hydrazine-1-carbothioamide intermediate II with benzaldehydes was described. Thiosemicarbazide intermediate II was obtained from reaction of 1-(4-aminophenyl)ethan-1-one and thiosemicarbazide. All synthesized compounds were screened for their antibacterial and antifungal activity by using agar well diffusion method. The results revealed that the compound I [X = H, OH, Y = H, 4-NH2] showed excellent activity against E. coli and moderate show against P. aerugenosaand and S.aureus. compound I [X = OH, Cl, Br; Y = H] were showed excellent against S.aureus. All compounds showed moderate anti-fungal activity against A. flavus and A. fumigates and show excellent against Candida albicans. In the experiment, the researchers used o-Bromobenzaldehyde(cas: 6630-33-7Product Details of 6630-33-7)
o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Product Details of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary