Poornima, B.; Venkanna, A.; Swetha, B.; Kamireddy, Karthik Reddy; Siva, Bandi; Phani Babu, V. S.; Ummanni, Ramesh; Babu, K. Suresh published the artcile< Total synthesis, biological evaluation of dendrodolides A-D and their analogues>, Quality Control of 16426-64-5, the main research area is dendrodolide synthesis anticancer.
A concise total synthesis of dendrodolides A-D has been accomplished in 10 steps from com. available (R)-propylene oxide and 3-buten-1-ol as starting materials. The key steps involved in the synthesis are Jacobsen hydrolytic kinetic resolution, epoxide ring opening with 2-allyl-1,3-dithiane, Yamaguchi esterification and ring-closing metathesis (RCM). In addition, a series of ester derivatives were prepared utilizing Yamaguchi esterification at the C-3 position of the dendrodolide core and screened for their efficacy against cancer cell lines.
Tetrahedron published new progress about Antitumor agents. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Quality Control of 16426-64-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary